In a German study, 386 children between the ages of 3 and 12 who had suffered bruises, sprains, strains, and muscle pain from playing sports were treated with Trauma comfrey. Trauma comfrey has also been tested for safety with children. The study author noted that the quick drop in pain levels allowed the patients to move their knees sooner, diminishing the possibility of further muscle damage due to immobility. None of the patients noted any reddening, itching, or dry skin. At day seven, no patients reported any knee pain while at rest, and most were completely pain-free by day 10. By that stage, pain and swelling had dropped considerably. Intensive treatment with comfrey and gauze wrapping was performed for four days. In another study, bruised and sprained knees were treated with Trauma comfrey cream within 12 hours of the injury. In a controlled, double-blind, randomized, multi-center study after using comfrey, patients suffering from acute ankle sprain and pain saw a 50- percent reduction of pain in just three days. In Germany, this variety of comfrey is known as Symphytum x uplandicum Nyman, and has been designated as “Trauma comfrey” by the German health authorities.Īside from soothing inflammation, comfrey treats many conditions life can throw your way, including open wounds, muscle pain, and knee and ankle sprains and strains. Thanks to a specialized comfrey that has PA-free flowers, stems, and leaves, the resulting topical cream made from it is completely safe for use. And doubts lingered about its safety as a topical, too, because it is readily absorbed through the skin. So for internal use, comfrey was off-limits. That’s because, as traditionally valuable as comfrey was considered to be, it was also discovered that the roots contain compounds called pyrrolizidine alkaloids (PAs) that can be toxic to the liver. To anyone familiar with herbal medicines, comfrey has had an “on- again, off-again” reputation as a healing plant. Fortunately, there is a botanical answer that is clinically tested and real-world ready, but its primary ingredient-comfrey-may come as a surprise.
#Symphytum officinale skin safety skin
Symphytum officinale allantoin antioxidant activity cell viability comfrey human skin fibroblast phenolic acids.Beyond the safe, natural and effective oral preparations for pain and inflammation, there is an increasing need for practitioners-and their patients-for a pain-reducing and healing topical aid.īut finding the right fit to take care of all the sprains, strains, and abrasions that come your way can be a challenge.Īfter all, you want something that works, is safe, has been put to the test, and can be used by children because you know the kind of skins and scrapes they can get. officinale root has strong antioxidant potential and a beneficial effect on human skin fibroblasts. The obtained results indicate that non-toxic extract from S. Moreover, no changes in cytoskeleton structure and cells shape were observed.
MTT test proved the stimulatory effect on cell metabolism and viability of HSF cells.
DPPH, FRAP and TPC assay showed the high antioxidant activity of the extract. Five compounds were found: rosmarinic, p-hydroxybenzoic, caffeic, chlorogenic and p-coumaric acid. Moreover, the quantification of main phenolics and allantoin was conducted using HPLC-DAD method. officinale in term of its antioxidant activity and the effect on cell viability and proliferation of human skin fibroblast (HSF). The objective of our investigation was to analyse the extract from S. is commonly used in folk medicine to promote the wound healing, reduce the inflammation and in the treatment of broken bones.
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